Kratom Alkaloid 7-Hydroxymitragynine: How It Works

Key Take Away

1. Potent Analgesic: 7 Hydroxymitragynine binds to µ-opioid receptors, offering pain relief with greater potency than traditional painkillers, but with a lower risk of certain adverse effects.
2. Dual Effects: It exhibits both stimulant and sedative effects, influenced by the dosage, which adds to its complex pharmacological profile.
3. Risk of Dependence: There is a potential for dependence and withdrawal, necessitating careful monitoring and moderation in use.
4. Therapeutic Potential: While promising for pain management and possibly aiding in opioid withdrawal, the lack of extensive research and standardization calls for a cautious approach.
5. Varied Legal Status: The legal stance on 7 Hydroxymitragynine is not uniform, reflecting the international debate on its safety and therapeutic value.

Kratom Alkaloids 7-Hydroxymitragynine

1. Introduction: My Thoughts

I have spent nearly a decade scouring documents and Government data bases seeking insights into the remarkable properties of Kratom alkaloids. Over the course of this research there has been numerous findings in the scientific world suggesting there maybe as much as 40 alkaloids that have been identified.

After speaking with thousands of people I have served it was clear Kratom and Kratom Alkaloids are a special botanical and it led me down a long rabbit hole to better understand each of these specific naturally occurring chemicals found in this awesome tree’s leaves.

Today I want to share with you detailed information about one particular chemical that has been associated with elevated mood, it’s not talked about often and usually found in lower percentages when you look at the finer details of lab reports.

SUMMARY

7 Hydroxymitragynine, a key alkaloid in Mitragyna Speciosa, it is recognized for its potent analgesic properties and complex pharmacological profile. While it offers potential benefits for pain management and opioid withdrawal assistance, its potential for dependence, varied legal status, and the lack of extensive research highlight the need for cautious, informed use.

2. Pharmacological Effects

7 Hydroxymitragynine is a potent alkaloid found in Kratom (Mitragyna speciosa), a tropical evergreen tree native to Southeast Asia. This compound, though present in smaller quantities compared to mitragynine (another major compound in Kratom Alkaloids), has garnered significant attention due to its pharmacological effects.

Initially, 7 Hydroxymitragynine binds primarily to the µ-opioid receptors in the brain, similar to opioid drugs, but with a distinct binding profile. Consequently, it exhibits potent analgesic effects, making it effective for pain relief. Studies suggest its analgesic potency is roughly 13 times that of morphine, albeit with a significantly lower risk of respiratory depression, a common side effect of traditional opioids.

Moreover, this compound also interacts with other receptor systems in the brain, including the κ- and δ-opioid receptors, which contributes to its complexity. For instance, it exhibits both stimulant and sedative effects, depending on the dose. At low doses, it can increase energy and alertness, while higher doses tend to lead to sedation.

3. Chemical Structure: What Is 7-Hydroxymitragynine

7 Hydroxymitragynine is an alkaloid derived from the Kratom plant (Mitragyna speciosa). It’s chemically known as a terpenoid indole alkaloid. The structural data for 7 Hydroxymitragynine is as follows:

• Chemical Formula: C₂₃H₃₀N₂O₅
• Molecular Weight: 414.5 g/mol
• IUPAC Name: Methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-hydroxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate

The molecule consists of:

• A terpenoid backbone
• An indole moiety
• A quinolizidine moiety

Structural Features:

1. Terpenoid Backbone: The core of the structure, derived from isoprene units, contributing to the molecule’s overall scaffold.
2. Indole Moiety: A bicyclic structure composed of a benzene ring fused to a pyrrole ring. This feature is crucial for the molecule’s interaction with opioid receptors.
3. Quinolizidine Moiety: This part of the molecule includes a double-ring system that is part of the molecule’s larger, complex ring structure.
4. Functional Groups:
   • Methoxy Group (–OCH₃): Attached to the terpenoid part of the molecule, influencing its solubility and reactivity.
   • Hydroxy Group (–OH): A hydroxyl group that increases polarity and may be involved in receptor interaction.
   • Ester Linkage (–COO–): Connects a methyl group to the main structure, playing a role in the molecule’s shape and biological activity.

The compound’s unique structure is responsible for its potent activity at the µ-opioid receptors, leading to its analgesic and sedative effects. The specific arrangement of atoms and functional groups in 7 Hydroxymitragynine’s structure is crucial for its interaction with biological targets, contributing to its pharmacological profile.

4. Potential for Dependence and Withdrawal

Significantly, 7 Hydroxymitragynine has a potential for dependence and withdrawal symptoms, although these are generally considered milder compared to traditional opioids. Chronic use can lead to tolerance, meaning users will require higher doses to achieve the same effects, which can increase the risk of adverse reactions.

Becoming dependent on this chemical is unlikely as it is usually much lower in percentage per gram than the primary mitragynine which is higher per gram. It’s critical to note this part to show a distinction between alkaloid profiles and their natural abundance.

5. Therapeutic Potential and Risks

Furthermore, while the therapeutic potential of 7 Hydroxymitragynine in managing pain and opioid withdrawal symptoms is promising, it is crucial to approach its use with caution. The lack of comprehensive clinical trials and the variability in Kratom plant composition necessitate careful consideration of its benefits against potential risks, including addiction and interaction with other substances.

This is a known fact as we have had millions of people who have used mitragyna speciosa for various purposes but mainly for opioid withdrawals and pain management long term. The truth is that there is far more potential for benefit than there is negative impacts, particularly when you use it with a purpose and responsibly at that. The abundance that Kratom Alkaloids provide in alleviating human suffering is immeasurable.

6. Regulatory Status

Importantly, the legal status of Kratom, mitragynine, 7 Hydroxymitragynine including all of the other alkaloid profiles vary globally, reflecting the ongoing debate about its safety profile. In some countries or states in America, it is classified as a controlled substance, while in others, it remains legal and unregulated while in many parts of the United States it’s become more regulated with the Senate Bill called Kratom Consumer Protection Act (KCPA).

The FDA has long had the stance of “Not For Human Consumption” and remains diligent in warning the public about it’s use with regular updates regarding unsubstantiated medical related illnesses. The information is out there for you to read so get to it and educate yourself on what is fact or fiction.

7. Concluding Thoughts: 7-Hydroxymitragynine

In conclusion, 7 Hydroxymitragynine emerges as a compound of significant interest and complexity within the realm of natural pharmacology. Its potent analgesic properties, coupled with a unique pharmacological profile, position it as a focal point in discussions surrounding pain management alternatives and the ongoing opioid crisis. However, the substance’s potential for dependence, variable legal status across jurisdictions, and the nascent stage of research into its effects and safety profile necessitate a prudent and informed approach to its use.

As the scientific community continues to unravel the intricacies of 7 Hydroxymitragynine, it is imperative for potential users and policymakers alike to balance the compound’s therapeutic promise with a mindful acknowledgment of its risks and the legal landscape that governs its application. The path forward should be paved with rigorous research, comprehensive understanding, and a commitment to public health and safety.

FAQs

Sources:

• PUBCHEM: https://pubchem.ncbi.nlm.nih.gov/compound/7-hydroxymitragynine
• NCCIH: https://www.nccih.nih.gov/

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• Kratom Extracts Guide What To Know Now
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Meet The Author

Mike Korlin

I have been studying and applying functional medicine in my personal life for nearly a decade. As a student, a retailer and a human being my knowledge is drawn from my own and thousands of other peoples experiences that I have spoken to or aided in discovering the wonderful world of plant medicines.