7-Hydroxymitragynine: What Kratom Shoppers Should Know

Key Take Away

1. Opioid-Receptor Activity: 7 Hydroxymitragynine binds to µ-opioid receptors, which is why researchers study it closely and why regulators treat it with caution.
2. Dual Effects: It exhibits both stimulant and sedative effects, influenced by the dosage, which adds to its complex pharmacological profile.
3. Risk of Dependence: There is a potential for dependence and withdrawal, necessitating careful monitoring and moderation in use.
4. Research Status: Researchers are still studying how this alkaloid works, and the lack of extensive research and standardization calls for a cautious approach.
5. Varied Legal Status: The legal stance on 7 Hydroxymitragynine is not uniform, reflecting the international debate on its safety and therapeutic value.

Kratom Alkaloids 7-Hydroxymitragynine

1. Introduction: My Thoughts

I have spent nearly a decade scouring documents and Government data bases seeking insights into the remarkable properties of Kratom alkaloids. Over the course of this research there has been numerous findings in the scientific world suggesting there maybe as much as 40 alkaloids that have been identified.

After speaking with thousands of people I have served it was clear Kratom and Kratom Alkaloids are a special botanical and it led me down a long rabbit hole to better understand each of these specific naturally occurring chemicals found in this awesome tree’s leaves.

Today I want to share with you detailed information about one particular chemical that has been associated with elevated mood, it’s not talked about often and usually found in lower percentages when you look at the finer details of lab reports.

SUMMARY

7 Hydroxymitragynine, a key alkaloid in Mitragyna Speciosa, it is recognized for its potent analgesic properties and complex pharmacological profile. Research on its effects is still early, and its potential for dependence, varied legal status, and the lack of extensive research highlight the need for cautious, informed use.

2. Pharmacological Effects

7 Hydroxymitragynine is a potent alkaloid found in Kratom (Mitragyna speciosa), a tropical evergreen tree native to Southeast Asia. This compound, though present in smaller quantities compared to mitragynine (another major compound in Kratom Alkaloids), has garnered significant attention due to its pharmacological effects.

Initially, 7 Hydroxymitragynine binds primarily to the µ-opioid receptors in the brain, similar to opioid drugs, but with a distinct binding profile. Laboratory studies describe strong activity at these receptors. In lab settings, it has been described as considerably more potent at opioid receptors than mitragynine.

Moreover, this compound also interacts with other receptor systems in the brain, including the κ- and δ-opioid receptors, which contributes to its complexity. For instance, it exhibits both stimulant and sedative effects, depending on the dose. At low doses, it can increase energy and alertness, while higher doses tend to lead to sedation.

3. My Experience Using 7-OH

About a year ago the excitement around this new compound was beginning to grow. As usual my business phone was ringing off the hook everyday, from people who were interested and looking to purchase it to manufacturers and distributors looking to get it into shops like mine. My process has always been to take it slow with new emerging products. First I research to understand the purpose of a product, then I determine if it has the potential to help people with a specific symptom or challenge. Once this is all done I begin looking at manufacturers, their process for extraction, the lab reports and everything in between (this part is critical for safe consumption).

So when I completed my assessment I began trials, my first experience was incredible. I always test supplements the same way, early morning after waking up I drink a large bottle of water, have my coffee and then I take the supplement. Empty stomach testing is the best approach I found to determine whether or not it’s effective and how effective. With food in your stomach it will typically yield results that are difficult to quantify. I began with half a tablet about 10mg of 7-OH and 15 minutes after that it began to work. I noticed an immediate effect on my mood. Have to say I felt awesome, the effect was much more noticeable compared to kratom’s effects on mood. I did note that I did not observe any effects on pain.

I loved the effect so much that I wanted to take another dose in the late afternoon. This is when I noticed one issue with it, that evening I couldn’t sleep that well, had vivid dreams all night and woke up feeling sleep deprived. So lesson learned, 7-OH is only for mornings atleast for me anyway.

This alkaloid compound found in kratom is usually very small and therefore requires extensive extraction with very large quantities of kratom which yields very small amounts of 7-OH. It unfortunately leads to very high prices per tablet or capsule, I find this to be the most annoying part, it’s a great compound and can help many people with general depression symptoms but if it costs too much then it’ll be out of reach for most.

• Available In Different Dosages: 10mg, 15mg, 20mg
• Fast Acting
• Incredible Mood Enhancer
• Lasts Several Hours

4. Chemical Structure: What Is 7-Hydroxymitragynine

7 Hydroxymitragynine is an alkaloid derived from the Kratom plant (Mitragyna speciosa). It’s chemically known as a terpenoid indole alkaloid. The structural data for 7 Hydroxymitragynine is as follows:

• Chemical Formula: C₂₃H₃₀N₂O₅
• Molecular Weight: 414.5 g/mol
• IUPAC Name: Methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-hydroxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate

The molecule consists of:

• A terpenoid backbone
• An indole moiety
• A quinolizidine moiety

Structural Features:

1. Terpenoid Backbone: The core of the structure, derived from isoprene units, contributing to the molecule’s overall scaffold.
2. Indole Moiety: A bicyclic structure composed of a benzene ring fused to a pyrrole ring. This feature is crucial for the molecule’s interaction with opioid receptors.
3. Quinolizidine Moiety: This part of the molecule includes a double-ring system that is part of the molecule’s larger, complex ring structure.
4. Functional Groups:
   • Methoxy Group (–OCH₃): Attached to the terpenoid part of the molecule, influencing its solubility and reactivity.
   • Hydroxy Group (–OH): A hydroxyl group that increases polarity and may be involved in receptor interaction.
   • Ester Linkage (–COO–): Connects a methyl group to the main structure, playing a role in the molecule’s shape and biological activity.

The compound’s unique structure is responsible for its potent activity at the µ-opioid receptors, leading to its analgesic and sedative effects. The specific arrangement of atoms and functional groups in 7 Hydroxymitragynine’s structure is crucial for its interaction with biological targets, contributing to its pharmacological profile.

5. Potential for Dependence and Withdrawal

Significantly, 7 Hydroxymitragynine has a potential for dependence and withdrawal symptoms, although these are generally considered milder compared to traditional opioids. Chronic use can lead to tolerance, meaning users will require higher doses to achieve the same effects, which can increase the risk of adverse reactions.

Becoming dependent on this chemical is unlikely as it is usually much lower in percentage per gram than the primary mitragynine which is higher per gram. It’s critical to note this part to show a distinction between alkaloid profiles and their natural abundance.

6. Therapeutic Potential and Risks

Furthermore, research into 7 Hydroxymitragynine is still at an early stage, so it is crucial to approach its use with caution. The lack of comprehensive clinical trials and the variability in Kratom plant composition necessitate careful consideration of its benefits against potential risks, including addiction and interaction with other substances.

Mitragyna speciosa has a long history of traditional use in Southeast Asia, but modern clinical research remains limited.

7. Regulatory Status

Importantly, the legal status of Kratom, mitragynine, 7 Hydroxymitragynine including all of the other alkaloid profiles vary globally, reflecting the ongoing debate about its safety profile. In some countries or states in America, it is classified as a controlled substance, while in others, it remains legal and unregulated while in many parts of the United States it’s become more regulated with the Senate Bill called Kratom Consumer Protection Act (KCPA).

The FDA has long had the stance of “Not For Human Consumption” and remains diligent in warning the public about it’s use with regular updates regarding unsubstantiated medical related illnesses. The information is out there for you to read so get to it and educate yourself on what is fact or fiction.

8. Concluding Thoughts: 7-Hydroxymitragynine

7 Hydroxymitragynine emerges as a compound of significant interest and complexity within the realm of natural pharmacology. Its unique pharmacological profile, including its activity at opioid receptors, has made it a focal point of research and regulatory discussion. However, the substance’s potential for dependence, variable legal status across jurisdictions, and the nascent stage of research into its effects and safety profile necessitate a prudent and informed approach to its use.

As the scientific community continues to unravel the intricacies of 7 Hydroxymitragynine, it is imperative for potential users and policymakers alike to balance the compound’s therapeutic promise with a mindful acknowledgment of its risks and the legal landscape that governs its application. The path forward should be paved with rigorous research, comprehensive understanding, and a commitment to public health and safety.

Have you tried this new kratom product? If so, please drop a comment below and share your experiences. It can help the masses determine whether or not they should try it too. Thanks for listening, watching and reading.

FAQs

Sources:

• PUBCHEM: https://pubchem.ncbi.nlm.nih.gov/compound/7-hydroxymitragynine
• NCCIH: https://www.nccih.nih.gov/

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Meet The Author

Mike Korlin

I have been studying and applying functional medicine in my personal life for nearly a decade. As a student, a retailer and a human being my knowledge is drawn from my own and thousands of other peoples experiences that I have spoken to or aided in discovering the wonderful world of plant medicines.